Current Research Studies

Current Cardiology Projects

Development and Evaluation of Novel PET-MR Acquisition and Reconstruction Techniques for Improved Diagnosis of Heart Disease

Current Neurology Projects

Tracers currently used in our neurology studies include: [¹⁸F]fallypride, [¹⁸F]florbetapir, [¹⁸F]florbetaben, [¹⁸F]DPA-714, [¹⁸F]GE-179.

Tracking myelin changes in vivo with ¹⁸F-florbetapen PET and MRI in patients with Multiple Sclerosis. A Proof of concept Pilot study
A phase III, randomized, placebo-controlled, parallel-group, double blind clinical trial to study the efficacy and safety of MK-8931 (SCH 900931) in subjects with amnestic Mild Cognitive Impairment due to Alzheimer's Disease (prodromal AD).
Investigating the role of glutamate and the N-methyl-D-aspartate-Receptor (NMDAR) in brain function
Investigating the effect of Continuous Positive Airway Pressure on the Neuropathology of Obstructive Sleep Apnoea (INCOSA)
Dopamine release and blood flow changes during induced epileptic seizures assessed with simultaneous PET-MR
The role of inflammation in brain and cognitive function in mental disorders (IRIS)
Evaluation of Brain PET/MR versus PET-CT

Current Oncology Projects

Tracers currently used in our oncology studies include: [¹⁸F]FDG, [¹⁸F]fluoride, [¹⁸F]choline, [¹⁸F]MISO, [⁶⁸Ga]PSMA, [¹⁸F]fluciclovine.

A Phase 1 Study of LY3039478 in Patients with Advanced or Metastatic Cancer (NOTCH)
MRI assessment of hypoxia and perfusion in primary colorectal cancer: Correlation with imaging and immunohistochemical markers of hypoxia (MATCH)
METfomin And Longevity (METAL): A window of opportunity study investigating biological effects of metformin in localised prostate cancer
A phase 3, open-label study to assess the utility of Fluciclovine (¹⁸F) Injection PET/CT in patients with prostate cancer with biochemical recurrence after initial treatment - BED007
A randomized double-blind phase 3 study of avelumab in combination with standard of care chemoradiotherapy (cisplatin plus definitive radiation therapy) versus standard of care chemoradiotherapy in the front-line treatment of patients with locally advanced squamous cell carcinoma of the head and neck - JAVELIN
An open label, single arm pilot study of OncoSil^TM, administered to study participants with unresectable locally advanced pancreatic adenocarcinoma, given in combination with FOLFIRINOX or gemcitabine+nab-paclitaxel chemotherapies - OncoSil PANCO
A pilot study of positron lymphography for pre-operative axillary nodal staging among breast cancer patients
A Phase 2b Open-label, Randomized Two-arm Study of Selinexor (KPT-330) with Low Dose Dexamethasone in Patients with Relapsed/Refractory Diffuse Large B-Cell Lymphoma (DLBCL) - SADAL
A Phase 1 Adaptive Dose-Escalation Study to Evaluate the Tolerability, Safety, Pharmacokinetics, and Antitumor Activity of ADCT-301 in Patients with Relapsed or Refractory Hodgkin Lymphoma and Non-Hodgkin Lymphoma ADCT-301-001A
Phase 2, Open-Label, Monotherapy, Multicenter Study to Evaluate the Efficacy and Safety of INCB054828 in Subjects With Myeloid/Lymphoid Neoplasms With FGFR1 Rearrangement - INCYTE HANK
TIDaL - Risk-stratified sequential Treatment with Ibrutinib and Rituximab (IR) and IR-CHOP for De-novo post-transplant Lymphoproliferative disorder (PTLD)
Histological correlation for textural features of PET & CT in NSCLC - FALCON
First international Inter-Group Study for nodular lymphocyte predominant Hodgkin`s Lymphoma in Children and Adolescents EuroNet-PHL-LP1
Functional Imaging for Response evaluation assessment in rectal cancer.
Evaluation of treatment response and resistance in metastatic renal cell cancer (mRCC) using integrated ¹⁸F-Fluorodeoxyglucose (¹⁸F-FDG) positron emission tomography/magneticresonance imaging (PET/MRI): The REMAP study
Response evaluation in myeloma patients using integrated 18F-Fluorodeoxyglucose (¹⁸F-FDG) positron emission tomography/magnetic resonance imaging (PET/MRI): The REVAMP study.
FABB: B A study using functional imaging biomarkers including ¹⁸F-fluoride PET, ¹⁸FDG PET and DW MRI to assess early treatment response in skeletal metastases from breast cancer.
FAB P - Functional Assessment of Bone metastases in Prostate cancer
Improving non-invasive diagnosis and characterisation of prostate cancer with PET/MRI - PROSPER
Histological correlation for textural features of PET &ceCT in NSCLC

Current Osteoporosis Projects

An open-label, single centre, pilot study exploring the impact of switching to Emtricitabine/Rilpivirine/Tenofovir Alafenamide (FTC/RPV/TAF) Fixed Dose Combination (FDC) on regional bone turnover measured using ¹⁸F-PET in HIV-1-infected patients virologically suppressed on Emtricitabine/Rilpivirine/Tenofovir Disoproxil Fumarate (FTC/RPV/TDF). PETRAM
A randomized, placebo-controlled study to assess the safety, tolerability, pharmacokinetics, and effects on heterotopic bone formation of regn2477 in patients with fibrodysplasia ossificans progressiva - REGENERON FOP