Current Cardiology Projects

• Heart-to-Brain Connection in pre-Heart Failure/pre-Dementia
• Development and Evaluation of Novel PET-MR Acquisition and Reconstruction Techniques for Improved Diagnosis of Heart Disease (Cardiac Pathway)
• Imaging guided in-vivo histological validation of cardiac sarcoid using 68Ga-DOTATATE and novel PET-MR methods (Cardiac sarcoid Dotatate)
• Does the measurement of elastin/ tropoelastin provide a mechanistic link for the detection of high-risk plaque?

Current Neurology Projects

Tracers currently used in our neurology studies include: [¹⁸F]florbetaben, [¹⁸F]DPA-714, [¹⁸F]FDG

• An investigation of short-chain fatty acid uptake in solid tumours by 18F-fluoropivalate positron emission tomography: Test-retest reproducibility (FPIA)
• Siderophores for Imaging Infection: A first-in-human pilot study using a tracer (68Ga-DFO) as proof of concept that siderophores can image bacterial infection in vascular grafts (GADFO)
• Atovaquone with Radical ChemorADIotherapy in locally Advanced NSCLC: A Phase I Trial of the Hypoxia Modifier Atovaquone in Combination with Radical Concurrent Chemoradiotherapy in Locally Advanced Non-Small Cell Lung Cancer
• Detection of acute cardiac toxicity in patients undergoing cancer treatment for lymphoma using novel PET/MR imaging (CONNECT)
• Adaptive Radiotherapy for Cancer of the Head and Neck guided by Intra-treatment 18F-FDG-PET and MRI scanning – a Phase 1 feasibility study (INGRES)
• Improving non-invasive diagnosis and characterisation of prostate cancer with PET/MRI (PROSPER)
• Evaluation of treatment response and resistance in metastatic renal cell cancer (mRCC) using integrated 18F-Fluorodeoxyglucose (18F-FDG) positron emission tomography/magnetic resonance imaging (PET/MRI): The REMAP study
• Response evaluation in myeloma patients using integrated 18F-Fluorodeoxyglucose (18F-FDG) positron emission tomography/magnetic resonance imaging (PET/MRI): The REVAMP study
• MRI assessment of hypoxia and perfusion in primary colorectal cancer: Correlation with imaging and immunohistochemical markers of hypoxia (MATCH)
• The role of PET/MRI in oncological imaging (PET/MR)
• A Randomised Phase II Evaluation of Molecular Guided Therapy for Diffuse Large B-Cell Lymphoma (DLBCL) with Acalabrutinib (REMODL A)
• A Phase 1-2, Open-Label Study of the Safety, Pharmacokinetics, Pharmacodynamics, and Preliminary Activity of Tolinapant in Combination with Oral Decitabine/Cedazuridine and Oral Decitabine/Cedazuridine Alone in Subjects with Relapsed/Refractory Peripheral T-cell Lymphoma (ASTX660-03)
• Histological correlation for textural features of PET &ceCT in NSCLC (FALCON)
• PET-Based Adaptive Radiotherapy Clinical Trial (PEARL)
• Measurement of PDL1 expression in cancer to monitor treatment response (PECan)

Current Oncology Projects

Tracers currently used in our oncology studies include: [¹⁸F]FDG, [¹⁸F]MISO, [⁶⁸Ga]PSMA, [⁶⁸Ga]DFO, [¹⁸F]FPIA

• A randomised double-blind placebo-controlled clinical trial investigating the effect and safety of oral semaglutide in subjects with early Alzheimer´s disease (EVOKE/EVOKE+ ) Protocol NN6535-4725 & NN6535-4730
• The role of inflammation in brain and cognitive function in mental disorders (IRIS)
• Evaluation of Brain PET/MR versus PET-CT